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August 2015

Volume 1 Issue 2
Research Article 

Lysoenzymuria as a Hypotetical Tracer for Evaluation of Nephrotoxicity in Patients with Rheumathoid Arthritis Treated with Most Used Slow  Acting Antirheumatic Drugs-Saards

Dejan Spasovski*

The aim of this study is to determine the effect of initial therapy with Methotrexate and Ketoprofen on glomerular and tubular integrity in patients with Rheumatoid arthritis (RA), to quantify nephrotoxicity of Methotrexate and Ketoprofen with measurement of enzyme excretion which correlates with the degree of damage of tubular epithelium. To determine whether there is a change in clinical and laboratory indicators of renal function (creatinin in serum and urine, serum urea, glomerular filtration rate (GFR) in course of the follow up of treatment and whether that change correlates with the dynamics of the quantity of enzymes excreted in urine and reactants of the acute phase: Rheumatoid factor (RF), C-reactive protein (CRP), Erythroicite sedimentation rate (ESR) and Index of intensity of disease (Disease Active Score DAS28).

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Original Article

Biomarkers and Choice of Biologic Agent: A Comparison of the Efficacy of Tocilizumab and Etanercept in Rheumatoid Arthritis Patients Presenting with Leukocytosis or Thrombocytosis

Kiyomitsu Miyachi, Belinda Sasse, So Nomoto

The aim of this study was to evaluate the relative efficacy of tocilizumab (TCZ) and etanercept (ETN) in patients with rheumatoid arthritis (RA) presenting with upper normal limit or high white blood cell (WBC) and platelet counts, and the relative roles of inflammatory cytokines TNFα and IL-6 on the appearance of these hematological abnormalities, by comparing laboratory results from RA patients pre and post administration of TCZ or ETN.

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Case Report

The Carbon Fiber Intramedullary Nail in Pathological Humeral Shaft Fractures: Two Case Reports

Maniscalco Pietro, Caforio Marco*, Groppi Giulia, Vallisa Daniele, Cavanna Luigi

The preferred surgical treatment of pathological humeral shaft fractures is the intramedullary nailing. A carbon-fiber-reinforced polyether ether ketone (CFR-PEEK) radiolucent nail allows for a stable internal fixation and better visualization of the fracture or pathological site on X-ray plain films, on computed tomography scan or magnetic resonance imaging also even the nail is in place, and enables a better power of radiation therapy in cases in which is indicated. Authors describe two clinical cases of patients with pathological humeral shaft fractures treated with this device until three months follow-up and discuss about the advantages and disadvantages of this new material.

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Original Article

Hip and Femoral Neck Morphometry In Correlation with Intertrochanteric Femur Fracture In Elderly

Dewo P. MD PhD, Nasrulloh M.MD, Lanodiyu Z*. MD, Magetsari R. MD PhD

Since the number of individuals older than 65 years is expected to double in 2040, several studies predict the prevalence of proximal femur fracture to rise significantly until 4.5 to 6.3 million worldwide by 2050. It become the most common injury pattern in patients older than 50 years and women has 3 times greater risk. Anatomically, hip fracture is divided into 3 categories, i.e, femoral neck fracture, intertrochanteric femur fracture, and subtrochanteric femur fracture. The incidence of hip fracture is associated with osteoporosis in older population. More than 250.000 hip fractures in US were said to have correlation with osteoporosis.

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Research Article

Randomized Study of Direct Anterior Approach versus Posterior Approach for Bipolar Hemiarthroplasty of the Hip

Hisaki Aiba* MD, Nobuyuki Watanabe MD PhD, Yasuhiro Nishimori MD PhD, Hiromi Onogi MD, Yusuke Oguri MD, Takashi Yamagami MD PhD, Hideki Okamoto MD PhD, Hironari Sakurai MD PhD,Takanobu Otsuka MD PhD

Femoral neck fractures have increased rapidly in line with the aging population in Japanese society. Bipolar hemiarthroplasty (BHA) is frequently used by many surgeons to treat femoral neck fractures, and many studies have subsequently reported good outcomes following the procedure. Several surgical approaches have been investigated for hip surgery. Using the direct anterior approach (DAA), muscle detachment can be avoided  and several studies have reported satisfactory outcomes due to rapid recovery of hip joint function after total hip arthroplasty (THA). However, many surgeons still prefer the posterolateral approach (PA) after becoming accustomed to it and reaching a plateau in their learning curve.

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